Type B Insulin Resistance in Peru.

Academic Article


  • Type B insulin resistance (IR) is a rare autoimmune disease characterized by the presence of insulin receptor autoantibodies, resulting in a marked IR inducing hyperglycemia. Our first case is a 42-year-old female with a history of RA, SLE and Hashimoto-thyroiditis that presented with cachexia, acanthosis-nigricans, hirsutism, negative anti-insulin-ab and glucose level between 400 to 700 mg/dl, despite a total insulin dose of 1000 IU/day. She received pulses of cyclophosphamide along with prednisone. One year later the patient was off insulin and with HbA1c of 5.6%. The second case is a 42-year-old female patient that presented with polyuria, polydipsia, cachexia, acanthosis-nigricans, negative glutamic-acid-decarboxilase-ab and positive TPO-ab. She received IV infusion of regular insulin at a rate of 500 UI/d. Two years later she was off insulin with HbA1C of 5.6%. As summary, we reported a case of a disease remitted after receiving immunosuppressive therapy and a case of disease remitted spontaneously.
  • Keywords

  • Developing country, Immunosuppressive therapy, Insulin resistance, Latin America, Peru, Adult, Autoantibodies, Autoimmune Diseases, Cyclophosphamide, Drug Therapy, Combination, Female, Humans, Immunosuppressive Agents, Insulin Resistance, Peru, Prednisone, Receptor, Insulin, Remission Induction
  • Digital Object Identifier (doi)

    Author List

  • Zelada H; Gamarra D; ArbaƱil H; Manrique H
  • Start Page

  • 258
  • End Page

  • 262
  • Volume

  • 353
  • Issue

  • 3