© 2020 World Federation of Orthodontists Background: This study was designed to determine if orthodontic treatment significantly changes the upper incisor position in Class I, II, and III dental and skeletal malocclusions. Methods: Ninety nonextraction-treated patients were included in this retrospective cohort study and divided into three groups: Class I, Class II, and Class III. All cephalometric measurements (ANB, Wits, U1-PP, U1-SN, U1-NA, U1 perpendicular to FH and U1-L1) were taken using the Dolphin Management and Imaging Software, Version 05.05.5070.221436 (United States and Canada). Results: The posttreatment values of ANB, Wits appraisal, U1-NA mm, U1-FH mm, IMPA and U1-L1° are statistically significant (P < 0.05) among the Class I, II, and III when compared with the normal values. Also ANB° changes after orthodontic treatment in Class I, II, and III were statistically significant with the greater changes in Class III malocclusion. Conclusions: There is a significant amount of dento-alveolar compensation for the maxillary incisors not only in patients with Class II and III but also in Class I malocclusions that underwent nonextraction treatments.