A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota

Academic Article

Abstract

  • A T cell receptor transgenic mouse line reactive to a microbiota flagellin, CBir1, was used to define mechanisms of host microbiota homeostasis. Intestinal IgA, but not serum IgA, was found to block mucosal flagellin uptake and systemic T cell activation in mice. Depletion of CD4+CD25+ Tregs decreased IgA+ B cells, total IgA, and CBir1-specific IgA in gut within days. Repletion of T cell-deficient mice with either CD4 +CD25+ or CD4+foxp3+ Tregs restored intestinal IgA to a much greater extent than their reciprocal CD4+ subsets, indicating that Tregs are the major helper cells for IgA responses to microbiota antigens such as flagellin. We propose that the major role of this coordinated Treg-IgA response is to maintain commensalism with the microbiota.
  • Digital Object Identifier (doi)

    Author List

  • Cong Y; Feng T; Fujihashi K; Schoeb TR; Elson CO
  • Start Page

  • 19256
  • End Page

  • 19261
  • Volume

  • 106
  • Issue

  • 46