Objectives: The aim of this study is to evaluate the reliability of measuring three-dimensional soft tissue morphology using a laser imaging system. Design: Prospective clinical trial. Materials and Methods: Thirty-eight adult subjects, mean age 24.5 years, were analyzed for soft tissue changes at baseline (T1) and at 1 week (T2) using two commercially available Minolta Vivid 900 (Osaka, Japan) laser scanning devices assembled as a stereopair. Left and right images were merged to form the whole face, and these images were superimposed to assess the errors between the two faces at T1 and at T2. Results: The results showed that the mean shell deviations for left and right scans at T1 were 0.32 ± 0.08 mm and 0.30 ± 0.09 mm for males and females, respectively. The mean shell deviations for left and right scans at T2 were 0.34 ± 0.08 mm and 0.32 ± 0.09 mm for males and females, respectively. The mean difference of the merged composite faces superimposed at T1 and T2 was 0.37 ± 0.07 mm and 0.35 ± 0.09 mm for males and females, respectively. Paired t-tests revealed that the mean difference of 0.02 mm was statistically insignificant (P > .05). The reproducibility error was 0.7 and 0.8 mm for females and males, respectively, when a tolerance of 90% was imposed on the aligned faces. Conclusions: Capturing soft tissue morphology of the face, using the technique described, is clinically reproducible within 1 week of the initial records. © 2006 by The EH Angle Education and Research Foundation, Inc.