007 (x2)-3-3: 14-3-3 Targeted Compounds as Double Agents

Academic Article

Abstract

  • © 2020 Elsevier Ltd 14-3-3 Proteins enact a range of cellular functions through protein–protein interactions (PPIs) with client proteins. Kaplan and colleagues recently demonstrated that a semisynthetic compound was able to selectively stabilize or disrupt specific interactions, depending on the binding partner. This finding presents an exciting possibility of designing other 14-3-3 compounds to regulate critical 14-3-3 interactions.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Gannon M; Yacoubian TA
  • Start Page

  • 431
  • End Page

  • 433
  • Volume

  • 41
  • Issue

  • 7