© 2020 Elsevier Inc. Background: The concept of sustainability has received growing attention since the adoption of the United Nations’ (UN) Sustainable Development agenda. Yet, in the context of sweeping changes regarding the status and profile of global nursing, sustainability has not been fully conceptualized. Purpose: To explore the concept of sustainability in global nursing in order to develop an operational definition and model. Methods: Concept analysis using Rodger's Evolutionary method to explicate the term “sustainability” in a global nursing context. Findings: Key features of sustainability were described. Existing models of global nursing focus on partnerships and lack a clear conceptualization and integration of sustainability. An operational definition and model of sustainability in global nursing were developed. Discussion: Evolutionary review and analysis led to clarity in operationalizing sustainability in global nursing. The definition and model compliment existing models and provide a road map for global nursing to contribute toward the UN Sustainable Development agenda.