FOXR2 Interacts with MYC to Promote Its Transcriptional Activities and Tumorigenesis.

Academic Article

Abstract

  • By combining the results of a large-scale proteomic analysis of the human transcription factor interaction network with knowledge databases, we identified FOXR2 as one of the top-ranked candidate proto-oncogenes. Here, we show that FOXR2 forms a stable complex with MYC and MAX and subsequently regulates cell proliferation by promoting MYC's transcriptional activities. We demonstrate that FOXR2 is highly expressed in several breast, lung, and liver cancer cell lines and related patient tumor samples, while reduction of FOXR2 expression in a xenograft model inhibits tumor growth. These results indicate that FOXR2 acts with MYC to promote cancer cell proliferation, which is a potential tumor-specific target for therapeutic intervention against MYC-driven cancers.
  • Authors

    Published In

  • Cell Reports  Journal
  • Keywords

  • FOXR2, MYC, forkhead box, protein-protein interaction, Animals, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Breast Neoplasms, Carcinogenesis, Cell Proliferation, Female, Forkhead Transcription Factors, Gene Expression, Gene Expression Regulation, Neoplastic, HEK293 Cells, Humans, MCF-7 Cells, Mice, Inbred BALB C, Mice, Nude, Neoplasm Transplantation, Protein Interaction Domains and Motifs, Protein Interaction Maps, Protein Multimerization, Protein Stability, Proto-Oncogene Proteins c-myc, Transcriptional Activation
  • Digital Object Identifier (doi)

    Author List

  • Li X; Wang W; Xi Y; Gao M; Tran M; Aziz KE; Qin J; Li W; Chen J
  • Start Page

  • 487
  • End Page

  • 497
  • Volume

  • 16
  • Issue

  • 2