Activity-dependent structural plasticity of dendritic spines



  • Neuroscientists have long been fascinated by the problem of how memory is formed, stored, and recalled. Cellular models of learning and memory propose that morphological remodeling of existing synapses and the formation of new ones lead to enduring changes in neuronal networks. We discuss the evidence of activity-dependent structural plasticity of dendritic spines in the hippocampus, focusing on the effects of environmental enrichment, behavioral learning, and in vitro manipulations of neuronal activity leading to synaptic plasticity. We review the actions of neurotrophins and hormones on dendritic spines in the context of hippocampal-dependent learning and memory. Finally, we discuss the consequences of abnormal dendritic spines for cognition and learning and memory in disorders associated with mental retardation.
  • Digital Object Identifier (doi)

    International Standard Book Number (isbn) 13

  • 9780123705099
  • Start Page

  • 695
  • End Page

  • 719