Leptin is essential in maintaining normal vascular compliance independent of body weight

Academic Article

Abstract

  • The adipocytokine leptin centrally regulates body weight by enhancing metabolic rate and signaling satiety, but it also has wide-ranging peripheral effects. Leptin receptors are expressed on vascular smooth muscle cells and have a role in maintaining vascular tone. We investigated the vascular effects of leptin repletion or calorie restriction on leptin-deficient mice (ob/ob) and a leptin antagonist on wild-type (WT) mice. Aortic compliance was assessed by the measurement of pulse wave velocity by noninvasive Doppler; blood pressure was measured by left ventricular catheterization. We found that ob/ob mice have much stiffer aortas than WT mice and that reduction in aortic stiffness was greater in ob/ob mice treated with leptin vs calorie restriction, despite similar weight loss. Interestingly, treating WT mice with a leptin antagonist increases aortic stiffness with no change in weight. Thus, we conclude that leptin is essential for maintaining normal aortic compliance independent of body weight. © 2010 Macmillan Publishers Limited. All rights reserved.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Sikka G; Yang R; Reid S; Benjo A; Koitabashi N; Camara A; Baraban E; O'Donnell CP; Berkowitz DE; Barouch LA
  • Start Page

  • 203
  • End Page

  • 206
  • Volume

  • 34
  • Issue

  • 1