© 2019, (publisher Name). All Rights Reserved. Malakoplakia is a rare mucosal lesion that can be seen with gastrointestinal endoscopy. This process is classically seen in the genitourinary tract, however the gastrointestinal tract is the second most common site of occurrence. Colonic malakoplakia is largely an incidental finding, rarely causing symptoms, but it can be associated with colon adenocarcinoma making it clinically significant. We present a case of colonic malakoplakia and discuss its management and clinical significance.