A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza viruses

Academic Article


  • Development of effective and immunogenic vaccines against highly pathogenic avian influenza H5N1 viruses with the potential to cause a pandemic is a public health priority. The global demand for a vaccine cannot be met in the event of an influenza pandemic because of the limited capacity to manufacture egg-derived vaccines as well as potential problems with the availability of embryonated eggs. Thus, there is an urgent need to develop alternative, egg-independent vaccines. We developed an adenoviral vector-based vaccine that contains hemagglutinin protein from clade 1 and clade 2 viruses, as well as conserved nucleoprotein, to broaden the vaccine coverage against H5N1 viruses. © 2008 by the Infectious Diseases Society of America. All rights reserved.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Hoelscher MA; Singh N; Garg S; Jayashankar L; Veguilla V; Pandey A; Matsuoka Y; Katz JM; Donis R; Mittal SK
  • Start Page

  • 1185
  • End Page

  • 1188
  • Volume

  • 197
  • Issue

  • 8