Emerging roles of TGF-β co-receptors in human disease

Chapter

Abstract

  • © 2013 Springer Japan. All rights reserved. TGF-β signaling is both regulated and mediated by signaling co-receptors. Several TGF-β co-receptors have been identified including endoglin (CD105), the type III TGF-β receptor (TβRIII, betaglycan), neuropilin-1/2, syndecan-2, CD109, and LRP1. These co-receptors serve diverse functions including the regulation of ligand acceβ to other TGF-β receptors and receptor trafficking. The TGF-β co-receptors can also signal directly. The TGF-β co-receptors are broadly expreβed, have eβential roles in embryonic development, and are frequently altered during disease progreβion. TGF-β co-receptors regulate cancer initiation and progreβion through effects on cell growth, migration, invasion, proliferation, and angiogenesis. In addition to their roles in cancer, these co-receptors are dysregulated during development, in vascular disease and fibrotic disorders. Collectively, the TGF-β co-receptors influence disease biology through complex mechanisms involving the regulation of growth factor-dependent and independent signaling events as well as through interactions with diverse scaffolding protein partners.
  • Digital Object Identifier (doi)

    International Standard Book Number (isbn) 10

  • 4431544089
  • International Standard Book Number (isbn) 13

  • 9784431544081
  • Start Page

  • 59
  • End Page

  • 89
  • Volume

  • 9784431544098