Improved Retinal Organoid Differentiation by Modulating Signaling Pathways Revealed by Comparative Transcriptome Analyses with Development In Vivo

Academic Article


  • Swaroop and colleagues performed transcriptome analysis of developing mouse retina in vivo and in organoids. Retinal organoid transcriptomes revealed altered expression of cell-type-specific genes associated with functional maturation and dysregulation of signaling pathways. Addition of DHA and FGF1 to organoid cultures facilitated an early and improved differentiation of photoreceptors.
  • Authors

    Published In

  • Stem Cell Reports  Journal
  • Digital Object Identifier (doi)

    Author List

  • Brooks MJ; Chen HY; Kelley RA; Mondal AK; Nagashima K; De Val N; Li T; Chaitankar V; Swaroop A
  • Start Page

  • 891
  • End Page

  • 905
  • Volume

  • 13
  • Issue

  • 5