Utility of Surface and Blood Polymerase Chain Reaction Assays in Identifying Infants With Neonatal Herpes Simplex Virus Infection

Academic Article

Abstract

  • Of 27 neonates with herpes simplex virus, DNAemia was observed in 100% with disseminated disease, 57% with central nervous system disease and 28% with skin, eye, mouth disease, suggesting DNAemia occurs frequently in these infants. Herpes simplex virus culture and polymerase chain reaction were performed on surface specimens from 13/27 infants, and ~50% tested positive only by polymerase chain reaction, suggesting the superiority of this technique.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Samies N; Jariwala R; Boppana S; Pinninti S
  • Start Page

  • 1138
  • End Page

  • 1140
  • Volume

  • 38
  • Issue

  • 11