CD8+ encephalitis: A severe but treatable HIV-related acute encephalopathy

Academic Article


  • Rapidly progressive encephalopathy in an HIV-positive patient presents a major diagnostic and management challenge. CD8+ encephalitis is a severe but treatable form of HIV-related acute encephalopathy, characterised by diffuse perivascular and intraparenchymal CD8+ lymphocytic infiltration. It can occur in patients who are apparently stable on antiretroviral treatment and probably results from viral escape into the central nervous system. Treatment, including high-dose corticosteroids, can give an excellent neurological outcome, even in people with severe encephalopathy and a very poor initial neurological status. We report a woman with CD8+ encephalitis, with a normal CD4 count and undetectable serum viral load, who made a good recovery despite the severity of her presentation.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Zarkali A; Gorgoraptis N; Miller R; John L; Merve A; Thust S; Jager R; Kullmann D; Swayne O
  • Start Page

  • 42
  • End Page

  • 46
  • Volume

  • 17
  • Issue

  • 1