Serum miR-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss

Academic Article

Abstract

  • Pancreatic beta-cell death is a major factor in the pathogenesis of type 1 diabetes (T1D), but straightforward methods to measure beta-cell loss in humans are lacking, underlining the need for novel biomarkers. Using studies in INS-1 cells, human islets, diabetic mice, and serum samples of subjects with T1D at different stages, we have identified serum miR-204 as an early biomarker of T1D-associated beta-cell loss in humans. MiR-204 is a highly enriched microRNA in human beta-cells, and we found that it is released from dying beta-cells and detectable in human serum. We further discovered that serum miR-204 was elevated in children and adults with T1D and in autoantibody-positive at-risk subjects but not in type 2 diabetes or other autoimmune diseases and was inversely correlated with remaining beta-cell function in recent-onset T1D. Thus, serum miR-204 may provide a much needed novel approach to assess early T1D-associated human beta-cell loss even before onset of overt disease.
  • Digital Object Identifier (doi)

    Author List

  • Xu G; Thielen LA; Chen J; Grayson TB; Grimes T; Bridges SL; Tse HM; Smith B; Patel R; Li P
  • Start Page

  • E723
  • End Page

  • E730
  • Volume

  • 317
  • Issue

  • 4