Adjuvant treatment of early colon cancer with micrometastases: Results of a national survey

Academic Article


  • Background and Objectives: Optimal adjuvant treatment for patients with Stage I/II colon cancer with micrometastases (MM) is unknown. Because there is no known adjuvant treatment-related benefit, we evaluated whether MM influenced treatment decisions. Method: Review of a national survey from members of the SSO and ASCO. Results: Of 602 survey responses, 305 (51%) stated that MM had significant prognostic value, 250 (42%) were unsure, and 47 (7%) did not believe that MM held prognostic value. Three hundred seventy-four (63%) would offer adjuvant therapy in the setting of MM, while 222 (37%) would not. Only 15% routinely performed IHC on lymph nodes. Medical oncologists were more likely to recommend adjuvant therapy compared to surgical oncologists (68% vs. 51%, P = 0.001). Conclusions: MM in colon cancer apparently influenced adjuvant treatment decisions absent known prognostic benefit. Prospective trials are needed to improve the selection of patients for systemic chemotherapy in early, node-negative colon cancer. Copyright © 2012 Wiley Periodicals, Inc.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 26957612
  • Author List

  • Short SS; Stojadinovic A; Nissan A; Wainberg Z; Dhall D; Yao K; Bilchik A
  • Start Page

  • 119
  • End Page

  • 122
  • Volume

  • 106
  • Issue

  • 2