© 2014 Keita. Background: The study examines the association of neighborhood socioeconomic deprivation and metaboli syndrome with inflammation Methods: The analysis included 19, 079 black and white participants from the REasons for Geographic And Racia Differences in Stroke Study who were age > 45 years at baseline. Logistic regression examined whethe neighborhood deprivation was associated with increased odds of METS and CRP-MetS Results: Among black adults, residing in the most deprived neighborhoods was associated with increased odd of obesity (p < .01), lower HDL (p < .001), high blood pressure (p < .01), elevated fasting glucose (p < .001) inflammation (p < .01), and CRP-MetS (p < .001). Among white adults, neighborhood deprivation was associate with higher waist circumference (p < .001), lower HDL (p < .001), higher triglycerides (p < .01), higher glucos (p < .001), higher BMI (p < .0001), higher blood pressure (p = .01), METS (p < .001), inflammation (p < .01) an CRP-MetS (p < .001) Conclusions: These findings highlight the role of neighborhood socioeconomic deprivation on METS an CRP-MetS for black and white adults. Interventions tailored to address the contextual effects of deprive neighborhoods may reduce the observed neighborhood disparities.