Cross-amyloid interaction of Aβ and IAPP at lipid membranes

Academic Article

Abstract

  • Membrane controlled protein assembly: A study of the amyloid interaction of the islet amyloid polypeptide (IAPP), β-amyloid (Aβ), and a mixture of both with an anionic model raft membrane showed the dominant effect of IAPP on the aggregation process and on the hydrogen-bonding pattern of the assemblies present in the mixture (see picture). The analysis of the interaction of Aβ with IAPP-GI-a non-amyloidogenic IAPP mimic-confirmed these findings. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
  • Published In

  • Angewandte Chemie  Journal
  • Digital Object Identifier (doi)

    Author List

  • Seeliger J; Evers F; Jeworrek C; Kapoor S; Weise K; Andreetto E; Tolan M; Kapurniotu A; Winter R
  • Start Page

  • 679
  • End Page

  • 683
  • Volume

  • 51
  • Issue

  • 3