Limb preference during conversational gestures may be a reflection of functional hemispheric asymmetries. In right-handers, speech and praxis are usually mediated by the left hemisphere and in conversation, right-handers gesture more with their right than left hand. However, patients with left hemisphere brain damage, who are aphasic and apraxic but not hemiplegic, may use their right hemisphere to compensate for their left. Therefore, we investigated spontaneous lateralized gesture production during conversation in a group of left hemisphere-damaged stroke patients, who were aphasic and apraxic but not hemiparetic, and compared their performance to a group of matched controls. Whereas the control group had a strong right-hand preference, the nonparetic but apraxic and aphasic stroke patients were as likely to produce gestures with the right, left, or both hands. © 1995 Academic Press, Inc.