Immunological functioning in Alzheimer's disease: Differential effects of relative left versus right temporoparietal dysfunction

Academic Article

Abstract

  • The cerebral hemispheres are differentially involved in regulating immunological functioning and the neuropathology associated with Alzheimer's disease (AD) is asymmetrical. Thus, subgroups of AD patients may exhibit different patterns of immunological dysfunction. We explored this possibility in a group of AD patients and found that patients with low white blood cell counts and low lymphocyte numbers exhibited better performance on tests of right temporoparietal functioning. Also, a significant positive relationship exists between lymph numbers and performance on a test of left temporoparietal functioning. Thus, some AD patients have greater immunological dysfunction based on relative left versus right temporoparietal functioning. © 2013 Elsevier B.V.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Foster PS; Roosa KM; Williams MR; Witt JC; Heilman KM; Drago V
  • Start Page

  • 128
  • End Page

  • 132
  • Volume

  • 263
  • Issue

  • 1-2