Synthesis and Evaluation of QS-7-Based Vaccine Adjuvants

Academic Article

Abstract

  • ¬© 2019 American Chemical Society. We have designed and synthesized two analogs (5 and 6) of QS-7, a natural saponin compound isolated from Quillaja saponaria (QS) Molina tree bark. The only structural difference between compound 5 and 6 is that 5 is acetylated at the 3- and 4-O positions of the quillaic acid C28 fucosyl unit while 6 is not. However, the two analogs show significantly different immunostimulant profiles. Compound 5 may potentiate a mixed Th1/Th2 (Th, T helper cells) immune response against the specific antigens while compound 6 may only induce a Th2-biased immunity. These results suggest that the 3- and/or 4-O acetyl groups of the fucosyl unit may play an important role in tuning the adjuvanticity of the QS-7 analogs, and compound 5 can serve as a structurally defined synthetic adjuvant when a mixed Th1/Th2 immune responses is desired.
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    Digital Object Identifier (doi)

    Author List

  • Wang P; ҆kalamera D; Sui X; Zhang P; Michalek SM
  • Start Page

  • 974
  • End Page

  • 981
  • Volume

  • 5
  • Issue

  • 6