Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

Academic Article

Abstract

  • Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P 10 6). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P 0.01; overall P 5 × 10 8) and 4 additional regions provided nominal evidence of replication (P 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.
  • Published In

  • Nature Genetics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Barrett JC; Clayton DG; Concannon P; Akolkar B; Cooper JD; Erlich HA; Julier C; Morahan G; Nerup J; Nierras C
  • Start Page

  • 703
  • End Page

  • 707
  • Volume

  • 41
  • Issue

  • 6