Efficient cycloisomerization of propargyl amides by electrophilic gold(I) complexes of KITPHOS monophosphines: A comparative study

Academic Article


  • Electrophilic gold(I) complexes of diphenyl- and dicyclohexylphosphino- based KITPHOS monophosphines catalyze the 5-exo-dig cycloisomerization of a range of propargyl amides to afford the corresponding alkylidene oxazolines; in all cases catalysts formed from diphenylphosphino-substituted KITPHOS monophosphines outperformed their dicyclohexylphosphino counterparts as well as that based on triphenylphosphine, an indication that the biaryl/biaryl-like framework may be responsible for imparting high catalyst efficiency. © 2010 American Chemical Society.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Doherty S; Knight JG; Hashmi ASK; Smyth CH; Ward NAB; Robson KJ; Tweedley S; Harrington RW; Clegg W
  • Start Page

  • 4139
  • End Page

  • 4147
  • Volume

  • 29
  • Issue

  • 18