Synthesis of the alkaloids (-)-heliotridane and (-)-isoretronecanol via π-allyltricarbonyliron lactam complexes.

Academic Article

Abstract

  • A novel synthesis of the pyrrolizidine alkaloids (-)-heliotridane (1) and (-)-isoretronecanol (2) is described. The key steps involve the conversion of a proline-derived carbamate (10) into the π-allyltricarbonyliron lactam complex (4) and the exhaustive carbonylation of this to give the pivotal intermediate γ-lactam (3). Lactam (3) has been converted into the title compounds by standard methods. © 1991.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Knight JG; Ley SV
  • Start Page

  • 7119
  • End Page

  • 7122
  • Volume

  • 32
  • Issue

  • 48