Asymmetric carbonyl-ene and Friedel-Crafts reactions catalysed by Lewis acid platinum group metal complexes of the enantiopure atropisomeric biaryl-like diphosphine (S)-Me 2-CATPHOS: A comparison with BINAP

Academic Article

Abstract

  • Lewis acid platinum and palladium complexes of (S)-Me 2-CATPHOS catalyse the carbonyl-ene reaction between allylbenzene derivatives and ethyl trifluoropyruvate to give the expected α-hydroxy esters with ee's up to 97%, while the corresponding reaction involving 2-allylfuran and thiophene was exclusively selective for Friedel-Crafts-type reactivity and gave the corresponding 2-hydroxy-trifluoromethyl ethyl esters in good yield and moderate to good enantioselectivity. © 2012 Elsevier Ltd. All rights reserved.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Doherty S; Knight JG; Mehdi-Zodeh H
  • Start Page

  • 209
  • End Page

  • 216
  • Volume

  • 23
  • Issue

  • 3-4