Satb2 determines miRNA expression and long-term memory in the adult central nervous system

Academic Article


  • © Jaitner et al. SATB2 is a risk locus for schizophrenia and encodes a DNA-binding protein that regulates higher-order chromatin configuration. In the adult brain Satb2 is almost exclusively expressed in pyramidal neurons of two brain regions important for memory formation, the cerebral cortex and the CA1-hippocampal field. Here we show that Satb2 is required for key hippocampal functions since deletion of Satb2 from the adult mouse forebrain prevents the stabilization of synaptic long-term potentiation and markedly impairs long-term fear and object discrimination memory. At the molecular level, we find that synaptic activity and BDNF up-regulate Satb2, which itself binds to the promoters of coding and non-coding genes. Satb2 controls the hippocampal levels of a large cohort of miRNAs, many of which are implicated in synaptic plasticity and memory formation. Together, our findings demonstrate that Satb2 is critically involved in long-term plasticity processes in the adult forebrain that underlie the consolidation and stabilization of context-linked memory.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Jaitner C; Reddy C; Abentung A; Whittle N; Rieder D; Delekate A; Korte M; Jain G; Fischer A; Sananbenesi F
  • Volume

  • 5
  • Issue

  • November2016