Candidate-gene approaches for studying complex genetic traits: Practical considerations

Academic Article

Abstract

  • Association studies with candidate genes have been widely used for the study of complex diseases. However, this approach has been criticized because of non-replication of results and limits on its ability to include all possible causative genes and polymorphisms. These challenges have led to pessimism about the candidate-gene approach and about the genetic analysis of complex diseases in general. We believe that these criticisms can be usefully countered with an appeal to the principles of epidemiological investigation.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Tabor HK; Risch NJ; Myers RM
  • Start Page

  • 391
  • End Page

  • 397
  • Volume

  • 3
  • Issue

  • 5