Impaired Tumor-Necrosis-Factor-α-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants

Academic Article


  • Children have a higher risk of developing asthma in low-LPS “clean” environments than adults. Bachus et al. demonstrate that infant mice require higher doses of LPS than adult mice to prevent Th2-dependent allergic responses because of the decreased ability to induce LPS-driven TNF-α production and TNFR-mediated CD11b + dendritic cell activation for Th2 cell suppression.
  • Published In

  • Immunity  Journal
  • Digital Object Identifier (doi)

    Author List

  • Bachus H; Kaur K; Papillion AM; Marquez-Lago TT; Yu Z; Ballesteros-Tato A; Matalon S; León B
  • Start Page

  • 225
  • End Page

  • 240.e4
  • Volume

  • 50
  • Issue

  • 1