HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design

Academic Article

Abstract

  • HIV-1 Env amino acid signatures associated with sensitivity to broadly neutralizing antibodies were systematically defined from large neutralization panels. V2 signatures were incorporated in a trivalent vaccine to enhance epitope exposure and to include common epitope variants, resulting in increased neutralization breadth against heterologous viruses in a guinea pig model.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Bricault CA; Yusim K; Seaman MS; Yoon H; Theiler J; Giorgi EE; Wagh K; Theiler M; Hraber P; Macke JP
  • Start Page

  • 59
  • End Page

  • 72.e8
  • Volume

  • 25
  • Issue

  • 1