Epistemological foundations of statistical methods for high-dimensional biology



  • Science, from the Latin scientia, means having knowledge. Epistemology is the study of how we come to and what constitutes knowledge. The biological sciences use empiricism and induction [1]. We make inferences, predictions, and estimations from data, commonly via statistical techniques. Confidence in our biological knowledge stems, partly, from confidence in our statistical methodology’s validity. This begs the question: “How do we derive knowledge about the validity of statistical methods such that they also enjoy a solid epistemological foundation” Although in more traditional fields there seems to be an implicitly shared understanding among purveyors of statistical methodology, writings on these second-order epistemological questions in statistical analysis are remarkably scarce as is a shared understanding in the field of high-dimensional biology (HDB).
  • International Standard Book Number (isbn) 13

  • 9780824754617
  • Start Page

  • 57
  • End Page

  • 75