Antibiotic susceptibility profiles for group B streptococci isolated from neonates, 1995-1998

Academic Article

Abstract

  • Antibiotic susceptibility profiles were analyzed for 119 invasive and 227 colonizing strains of group B streptococci isolated from neonates at 6 US academic centers. All strains were susceptible to penicillin, vancomycin, chloramphenicol, and cefotaxime. The rate of resistance to erythromycin was 20.2% and to clindamycin was 6.9%. Resistance to erythromycin increased in 1997. Type V strains were more resistant to erythromycin than were type Ia (P = .003) and type Ib (P = .004) strains and were more resistant to clindamycin than were type Ia (P < .001), type Ib (P = .01), and type III (P = .001) strains. Resistance rates varied with geographic region: in California, there were high rates of resistance to erythromycin and clindamycin (32% and 12%, respectively), and low rates in Florida (8.5% and 2.1%, respectively). Penicillin continues to be the drug of choice for treatment of group B streptococcus infection. For women who are penicillin intolerant, however, the selection of an alternative antibiotic should be guided by contemporary resistance patterns observed in that region.
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    Digital Object Identifier (doi)

    Author List

  • Lin FYC; Azimi PH; Weisman LE; Philips JB; Regan J; Clark P; Rhoads GG; Clemens J; Troendle J; Pratt E
  • Start Page

  • 76
  • End Page

  • 79
  • Volume

  • 31
  • Issue

  • 1