Antibiotic susceptibility profiles for group B streptococci isolated from neonates, 1995-1998.

Academic Article

Abstract

  • Antibiotic susceptibility profiles were analyzed for 119 invasive and 227 colonizing strains of group B streptococci isolated from neonates at 6 US academic centers. All strains were susceptible to penicillin, vancomycin, chloramphenicol, and cefotaxime. The rate of resistance to erythromycin was 20.2% and to clindamycin was 6.9%. Resistance to erythromycin increased in 1997. Type V strains were more resistant to erythromycin than were type Ia (P=.003) and type Ib (P=.004) strains and were more resistant to clindamycin than were type Ia (P<.001), type Ib (P=.01), and type III (P=.001) strains. Resistance rates varied with geographic region: in California, there were high rates of resistance to erythromycin and clindamycin (32% and 12%, respectively), and low rates in Florida (8.5% and 2.1%, respectively). Penicillin continues to be the drug of choice for treatment of group B streptococcus infection. For women who are penicillin intolerant, however, the selection of an alternative antibiotic should be guided by contemporary resistance patterns observed in that region.
  • Published In

    Keywords

  • Anti-Bacterial Agents, Bacterial Capsules, Cefotaxime, Chloramphenicol, Clindamycin, Drug Resistance, Microbial, Erythromycin, Female, Humans, Infant, Newborn, Microbial Sensitivity Tests, Ofloxacin, Penicillins, Sepsis, Serotyping, Streptococcal Infections, Streptococcus agalactiae, Tetracycline, Vancomycin
  • Digital Object Identifier (doi)

    Author List

  • Lin FY; Azimi PH; Weisman LE; Philips JB; Regan J; Clark P; Rhoads GG; Clemens J; Troendle J; Pratt E
  • Start Page

  • 76
  • End Page

  • 79
  • Volume

  • 31
  • Issue

  • 1