Renal kallikrein excretion and epigenetics in human acute kidney injury: Expression, mechanisms and consequences



  • The incidence of acute kidney injury (AKI) in hospitalized patients is estimated to be 5-10%, and is much higher in the critically ill [1,2]. Despite the potential for recovery of kidney function, acute kidney injury is associated with substantial morbidity and even mortality. AKI, due to ischemia or nephrotoxic agent exposure, may lead to death or sublethal injury of proximal tubular cells, after which surviving cells may repolarize and/or de-differentiate, proliferate, migrate to denuded areas, re-differentiate, and restore nephron structure (including the tubular epithelium) and function [3,4].
  • Authors

    Digital Object Identifier (doi)

    International Standard Book Number (isbn) 13

  • 9781771880367
  • Start Page

  • 1
  • End Page

  • 28