Suppression of human melanoma metastasis by introduction of chromosome 6 may be partially due to inhibition of motility, but not to inhibition of invasion

Academic Article

Abstract

  • Active cellular motility and invasion play essential roles in metastasis. Introduction of normal, neo-tagged human chromosome 6 (neo6) into highly metastatic human melanoma cell line C8161 results in complete suppression of metastasis in vivo. To understand the mechanism by which metastasis was inhibited in neo6/C8161 hybrids, two in vitro assays, pseudopod protrusion and Membrane Invasion Culture System, were used to measure motility and invasion, respectively. neo6/C8161 hybrids are much less motile although they remained invasive, indicating that a metastasis-suppressor gene(s) on human chromosome 6 may regulate cellular motility, thereby inhibiting metastasis. © 1995 by Academic Press, Inc.
  • Digital Object Identifier (doi)

    Pubmed Id

  • 8150850
  • Author List

  • You J; Miele ME; Dong C; Welch DR
  • Start Page

  • 476
  • End Page

  • 484
  • Volume

  • 208
  • Issue

  • 2