APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies.

Academic Article


  • INTRODUCTION: Although the apolipoprotein E ε4-allele (APOE-ε4) is a susceptibility factor for Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), its relationship with imaging and cognitive measures across the AD/DLB spectrum remains unexplored. METHODS: We studied 298 patients (AD = 250, DLB = 48; 38 autopsy-confirmed; NCT01800214) using neuropsychological testing, volumetric magnetic resonance imaging, and APOE genotyping to investigate the association of APOE-ε4 with hippocampal volume and learning/memory phenotypes, irrespective of diagnosis. RESULTS: Across the AD/DLB spectrum: (1) hippocampal volumes were smaller with increasing APOE-ε4 dosage (no genotype × diagnosis interaction observed), (2) learning performance as assessed by total recall scores was associated with hippocampal volumes only among APOE-ε4 carriers, and (3) APOE-ε4 carriers performed worse on long-delay free word recall. DISCUSSION: These findings provide evidence that APOE-ε4 is linked to hippocampal atrophy and learning/memory phenotypes across the AD/DLB spectrum, which could be useful as biomarkers of disease progression in therapeutic trials of mixed disease.
  • Authors

    Published In


  • APOE, Alzheimer's disease, Dementia with Lewy bodies, Endophenotype, Hippocampus, Learning, MRI, Memory
  • Digital Object Identifier (doi)

    Pubmed Id

  • 8900705
  • Author List

  • Saeed U; Mirza SS; MacIntosh BJ; Herrmann N; Keith J; Ramirez J; Nestor SM; Yu Q; Knight J; Swardfager W
  • Start Page

  • 1137
  • End Page

  • 1147
  • Volume

  • 14
  • Issue

  • 9