Six-month hemoglobin concentration and its association with subsequent mortality among adults on antiretroviral therapy in Lusaka, Zambia

Academic Article

Abstract

  • Little is known about changes in hemoglobin concentration early in the course of antiretroviral therapy and its subsequent relation to survival. We analyzed data for 40,410 HIV-infected adults on antiretroviral therapy in Lusaka, Zambia. Our main exposure of interest was 6-month hemoglobin, but we stratified our analysis by baseline hemoglobin to allow for potential effect modification. Patients with a 6-month hemoglobin <8.5 g/dL, regardless of baseline, had the highest hazard for death after 6 months (hazard ratio: 4.5; 95% confidence interval: 3.3 to 6.3). Future work should look to identify causes of anemia in settings such as ours and evaluate strategies for more timely diagnosis and treatment. © 2012 Lippincott Williams & Wilkins.
  • Authors

    Digital Object Identifier (doi)

    Pubmed Id

  • 24076540
  • Author List

  • Giganti MJ; Limbada M; Mwango A; Moyo C; Mulenga LB; Brad Guffey M; Mulenga PL; Bolton-Moore C; Stringer JSA; Chi BH
  • Start Page

  • 120
  • End Page

  • 123
  • Volume

  • 61
  • Issue

  • 1