Auras localized to the temporal lobe disrupt verbal memory and learning — Causal evidence from direct electrical stimulation of the hippocampus

Academic Article

Abstract

  • © 2018 The Authors Auras (focal aware seizure; FAS) are subjective ictal events with retained consciousness. Epileptiform activities can disrupt cognitive tasks, but studies are limited to seizures with impaired awareness. As a proof of concept, we examined the cognitive effects of direct electrical stimulation to the left hippocampus which induced a habitual FAS in a patient with left mesial temporal lobe epilepsy. During the induced habitual FAS, verbal memory performance declined significantly as compared to pre-stimulation testing. Tasks measuring auditory working memory and psychomotor processing speed were not affected by the stimulation. The study confirms that FAS can impair episodic verbal memory and learning.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 8703378
  • Author List

  • Pizarro D; Toth E; Irannejad A; Riley KO; Jaisani Z; Muhlhofer W; Martin R; Pati S
  • Start Page

  • 99
  • End Page

  • 101
  • Volume

  • 10