Synthesis of certain 2′-Deoxy-3′,5′-di-O-benzyl-4′- thio-nucleosides using natural phosphate doped with trifluoromethanesulfonic acid as catalyst

Academic Article

Abstract

  • A series of 2′-deoxy-4′-thionucleosides are synthesized by coupling 1-O-acetyl-2-deoxy-3,5-di-O-benzyl-4-thio-D-erythro-pentufuranose to trimethylsilylated nucleobases using natural phosphate doped with trifluoromethanesulfonic acid as catalyst. The detail of this one-pot method and the comparison between the percentage of and -2′-deoxy-4′- thionucleosides with those described previously are also reported.
  • Digital Object Identifier (doi)

    Author List

  • Moukha-Chafiq O; Secrist JA; Lazrek HB
  • Start Page

  • 76
  • End Page

  • 81
  • Volume

  • 184
  • Issue

  • 1