Syntheses of phosphonate analogues of dideoxyadenosine (dda)-, dideoxycytidine (ddc)-, dideoxyinosine (ddi)-, and deoxythymidine (ddt)-51-Moriophosphates

Academic Article

Abstract

  • Phosphonate derivatives of ddA, ddC, ddI and ddT (5f, 5e, 5c, and 5a) were prepared by condensing the 5'-aldehydes with diphenyl triphenylphosphoranylidenemethylphosphonate, reducing the resultant olefins and hydrolyzing the phosphonate phenyl esters, sequentially, with base and then C. atrox phosphodiesterase. © 1992, Taylor & Francis Group, LLC. All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • Secrist JA; Montgomery JA; Riggs RM; Comber RN
  • Start Page

  • 947
  • End Page

  • 956
  • Volume

  • 11
  • Issue

  • 2-4