8-Substituted Purine Ribosides: Synthesis And Biological Activity

Academic Article

Abstract

  • The syntheses of a series of 8-substituted purine ribofuranosides are described. Reductive deamination of 8-bromoadenosine triacetate (1) provides the key intermediate (2) for subsequent displacement reactions. Four compounds show significant activity in two cell culture screens. © 1989, Taylor & Francis Group, LLC. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Shortnacy AT; Montgomery JA; Secrist JA
  • Start Page

  • 911
  • End Page

  • 913
  • Volume

  • 8
  • Issue

  • 5-6