Multi-log cytotoxicity of carbocyclic 2'-deoxyguanosine in HSV-TK-expressing human tumor cells.

Academic Article

Abstract

  • Ganciclovir (GCV) is widely used as a prodrug for selective activation in tumor cells expressing herpes simplex virus thymidine kinase (HSV-TK) because of its ability to induce multi-log cytotoxicity to HSV-TK-expressing as well as nonexpressing bystander cells. We now report that another substrate for HSV-TK, D-carbocyclic 2'-deoxyguanosine (CdG), induces multi-log cytotoxicity in HSV-TK-expressing and bystander cells at concentrations
  • Published In

  • Human Gene Therapy  Journal
  • Keywords

  • Antiviral Agents, Cell Death, Colonic Neoplasms, Deoxyguanosine, Enzyme Activation, Ganciclovir, Gene Transfer Techniques, Glioblastoma, Prodrugs, Simplexvirus, Thymidine Kinase, Tumor Cells, Cultured, Viral Proteins
  • Digital Object Identifier (doi)

    Author List

  • Shewach DS; Murphy PJ; Robinson BW; Vuletich J; Boucher PD; Blobaum AL; Zerbe L; Secrist JA; Parker WB
  • Start Page

  • 543
  • End Page

  • 551
  • Volume

  • 13
  • Issue

  • 4