Comparative tumor-initiating activity of methylated benzo(a)pyrene derivatives in mouse skin.

Academic Article

Abstract

  • The abilities of various mono and dimethyl derivatives of benzo(a)pyrene (BP) to initiate skin tumors in mice were determined by using a two-stage system of tumorigenesis. 11-Methylbenzo(a)pyrene was found to be approximately 3 times more active as a tumor initiator than was the parent hydrocarbon; 1-methyl benzo(a)pyrene was about twice as active as was BP. Substitution of a methyl group in positions 7, 8, 9, or 10 of BP, which would be involved in a bay-region diol-epoxide, completely counteracts the tumor-initiating ability of BP. 3-, 4-, and 12-methyl-benzo(a)pyrenes and activity equivalent to that of BP, whereas 2-, 5-, and 6-methylbenzo(a)pyrenes, as well as 1,2-, 4,5-, 1,6-, and 3,6-dimethylbenzo(a)pyrenes, were all less active than BP. The concepts of steric inhibition of metabolic activation and stereospecific activation are suggested to explain the tumor-initiating activities of various methylated derivatives.
  • Published In

  • Cancer Research  Journal
  • Keywords

  • Animals, Benzopyrenes, Cocarcinogenesis, Female, Methylation, Mice, Neoplasms, Experimental, Papilloma, Skin Neoplasms, Structure-Activity Relationship, Tetradecanoylphorbol Acetate
  • Pubmed Id

  • 10921779
  • Author List

  • Iyer RP; Lyga JW; Secrist JA; Daub GH; Slaga TJ
  • Start Page

  • 1073
  • End Page

  • 1076
  • Volume

  • 40
  • Issue

  • 4