2-Fluoroformycin and 2-aminoformycin. Synthesis and biological activity.

Academic Article

Abstract

  • Syntheses of 2-fluoroformycin [7-amino-5-fluoro-3-(beta-D-ribofuranosyl)pyrazolo[4,3-d]pyrimidine] (2b) and 2-aminoformycin [5,7-diamino-3-(beta-D-ribofuranosyl)pyrazolo[4,3-d]pyrimidine] (2c) are described. Cytotoxicity data are given for 2b and 2c alone as well as with added pentostatin. Kinetic parameters for adenosine deaminase are also provided. 2-Fluoroformycin, although a much poorer substrate for adenosine deaminase than formycin A, is not nearly as cytotoxic to cells in culture.
  • Published In

    Keywords

  • Adenosine, Adenosine Deaminase, Animals, Antibiotics, Antineoplastic, Formycins, Kinetics, Leukemia L1210, Nucleotides, Phosphates, Substrate Specificity
  • Author List

  • Secrist JA; Shortnacy AT; Montgomery JA
  • Start Page

  • 1740
  • End Page

  • 1742
  • Volume

  • 28
  • Issue

  • 11