Phosphate modified analogues of 5'O-phosphorylated 2', 3'-dldeoxynucleosides: Synthesis and Anti-HIV activity

Academic Article

Abstract

  • Phosphonate analogues of 5'-0-phosphoryl-2'3'-dideoxyribofuranosyl adenine, cytosine, hypoxanthine and thymine were synthesized. The hypoxanthine and thymine analogues were inactive against HIV induced cytopathy in the CEM-4 T-cell lines. The 2'3'-ddC and 2', 3'-ddA analogues were marginally active. © 1989, Taylor & Francis Group, LLC. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Authorlist

  • Secrist JA
  • Start Page

  • 1119
  • End Page

  • 1120
  • Volume

  • 8
  • Issue

  • 5-6