Progress in the synthesis of a potential PNP transition state inhibitor

Academic Article


  • Phosphonic acid la has been proposed as a multisubstrate analog of the suggested transition state 1 for the PNP catalyzed reversible conversion of inosine and phosphate to hypoxanthine and ribose-1-phosphate. A 20 step synthesis of the monoethyl ester lb from D-fructose is described. © 1989, Taylor & Francis Group, LLC. All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • Elliott RD; Niwas S; Montgomery JA; Secrist JA
  • Start Page

  • 1103
  • End Page

  • 1105
  • Volume

  • 8
  • Issue

  • 5-6