Concise assembly of linear α(1→6)-linked octamannan fluorescent probe

Academic Article


  • Synthesis of a fluorescently labelled (dansylated) linear α(1→6)-linked octamannan, using glycosyl fluoride donors and thioglycosyl acceptors, is described. A selective and convergent two-stage activation progression was executed to construct di-, tetra, and octa-mannosyl thioglycosides in three glycosylation steps with excellent yield. Further, a 5-N,N-dimethylaminonaphthalene-1-sulfonamidoethyl (dansyl) group was coupled to 1-azidoethyl octamannosyl thioglycoside. Global deprotection of the coupled product afforded the desired dansylated homo-linear α(1→6)-linked octamannan. © 2008 Elsevier Ltd. All rights reserved.
  • Authors

    Digital Object Identifier (doi)

    Pubmed Id

  • 12879322
  • Author List

  • Aqueel MS; Pathak V; Pathak AK
  • Start Page

  • 7157
  • End Page

  • 7160
  • Volume

  • 49
  • Issue

  • 50