Synthesis and anticonvulsant activity of some substituted lactams and amides.

Academic Article

Abstract

  • Thirteen derivatives of 3-phenyl-2-piperidinone were synthesized and evaluated for anticonvulsant activity. The most active compounds from this group included two simple lactams, 3-hydroxy-1-methyl-3-phenyl-2-piperidinone and 3-methoxy-3-phenyl-2-piperidinone, and two N-ethoxycarbonyl lactams, 1-(ethoxycarbonyl)-3-hydroxy-3-phenyl-2-piperidinone and 1-(ethoxycarbonyl)-3-methoxy-3-phenyl-2-piperidinone, whose anticonvulsant activity was comparable to or better than that for valproic acid. Four related acyclic amides were also prepared, but these were essentially inactive as anticonvulsants.
  • Published In

    Keywords

  • Amides, Animals, Anticonvulsants, Chemical Phenomena, Chemistry, Lactams, Mice, Piperidines, Seizures, Structure-Activity Relationship
  • Authorlist

  • Brouillette WJ; Grunewald GL
  • Start Page

  • 202
  • End Page

  • 206
  • Volume

  • 27
  • Issue

  • 2