Synthesis and Anticonvulsant Activity of Some Substituted Lactams and Amides

Academic Article


  • Thirteen derivatives of 3-phenyl-2-piperidinone were synthesized and evaluated for anticonvulsant activity. The most active compounds from this group included two simple lactams, 3-hydroxy-l-methyl-3-phenyl-2-piperidinone and 3-methoxy-3-phenyl-2-piperidinone, and two IV-ethoxycarbonyl lactams, l-(ethoxycarbonyl)-3-hydroxy-3-phenyl-2-piperidinone and l-(ethoxycarbonyl)-3-methoxy-3-phenyl-2-piperidinone, whose anticonvulsant activity was comparableto or better than that for valproic acid. Four related acyclic amides were also prepared, but these were essentially inactive as anticonvulsants. © 1984, American Chemical Society. All rights reserved.
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    Digital Object Identifier (doi)

    Author List

  • Brouillette WJ; Grunewald GL
  • Start Page

  • 202
  • End Page

  • 206
  • Volume

  • 27
  • Issue

  • 2