Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice

Academic Article

Abstract

  • In vitro screening of thiacetazone derivatives indicated that two derivatives, SRI-286 and SRI-224, inhibited a panel of 25 Mycobacterium avium complex (MAC) isolates at concentrations of 2 μg/ml or lower. In mice, SRI-224 and thiacetazone had no significant activity against the MAC in livers and spleens, but treatment with SRI-286 resulted in significant reduction of bacterial loads in livers and spleens. A combination of SRI-286 and moxifloxacin was significantly more active than single drug regimens in liver and spleen.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Bermudez LE; Reynolds R; Kolonoski P; Aralar P; Inderlied CB; Young LS
  • Start Page

  • 2685
  • End Page

  • 2687
  • Volume

  • 47
  • Issue

  • 8