Retinal nerve fiber layer thickness in glaucomatous Nepalese eyes and its relation with visual field sensitivity.

Academic Article


  • BACKGROUND: To evaluate peripapillary retinal nerve fiber layer (RNFL) thickness in glaucomatous Nepalese eyes using spectral domain optical coherence tomography (SD-OCT) and study its relationship with visual field sensitivity. METHODS: A total of 120 eyes comprising primary open angle glaucoma (POAG), glaucoma suspects (GS), normal tension glaucoma (NTG) and healthy subjects (n=30 cases in each group) underwent a complete ophthalmic examination, including optic nerve head (ONH) evaluation and standard automated perimetry (SAP). RNFL thickness measurements around the optic disk were taken with circular spectral domain optical coherence tomography (SD-OCT) scans. Analysis of variance (ANOVA) was used for comparison of RNFL parameters among various study groups. The relationship of RNFL parameters with visual field (VF) global indices was evaluated with regression analysis. RESULTS: The mean pRNFL thickness was significantly less in the POAG (64.30±14.45μm, p<0.01), NTG (85.43±9.79μm, p<0.001) and GS (102.0±9.37μm, p<0.001) groups than in the healthy group (109.8±8.32μm). The RNFL was significantly thinner across all quadrants in all study group pairs (p<0.05) except for normal vs. GS (only superior and inferior quadrant, significant). Linear regression plots with RNFL thickness as a predictor of MD and LV demonstrated a strong and statistically significant degree of determination in the POAG group (R(2)=0.203 and 0.175, p=0.013 and 0.021). CONCLUSION: The RNFL thickness measurements with SD-OCT are lower in glaucomatous eyes as compared to age-matched GS and normal eyes in the Nepalese population. A high resolution SD-OCT could aid significantly in the early diagnosis of glaucoma in Nepal.
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    Published In


  • Campo visual, Capa de fibras nerviosas, Glaucoma, Glaucoma primario de ángulo abierto, Nerve fiber layer, Optical coherence tomography, Primary open angle glaucoma, Tomografía de coherencia óptica, Visual field, Adult, Analysis of Variance, Asian Continental Ancestry Group, Case-Control Studies, Cross-Sectional Studies, Early Diagnosis, Female, Glaucoma, Humans, Male, Middle Aged, Nepal, Nerve Fibers, Retinal Ganglion Cells, Tomography, Optical Coherence, Visual Fields
  • Digital Object Identifier (doi)

    Pubmed Id

  • 18494615
  • Author List

  • Khanal S; Thapa M; Racette L; Johnson R; Davey PG; Joshi MR; Shrestha GS
  • Start Page

  • 217
  • End Page

  • 224
  • Volume

  • 7
  • Issue

  • 4