Klotho, the Key to Healthy Brain Aging?

Academic Article


  • Brain expression of klotho was first described with the initial discovery of the klotho gene. The prominent age-regulating effects of klotho are attributed to regulation of ion homeostasis through klotho function in the kidney. However, recent advances identified brain functions and cell populations, including adult hippocampal neural progenitors, which require klotho. As well, both human correlational studies and mouse models of disease show that klotho is protective against multiple neurological and psychological disorders. This review focuses on current knowledge as to how the klotho protein effects the brain.
  • Published In

  • Brain Plasticity  Journal
  • Keywords

  • Cognition, aging, long-term potentiation, neurogenesis, oligodendrocyte, oxidative stress, striatum, synaptic plasticity, white matter
  • Digital Object Identifier (doi)

    Pubmed Id

  • 9420774
  • Author List

  • Vo HT; Laszczyk AM; King GD
  • Start Page

  • 183
  • End Page

  • 194
  • Volume

  • 3
  • Issue

  • 2